Diabetes may be caused due to failure of privileged few cells


Research have come up with a fact that diabetes may be caused as a result of the failure of few cells and not all of the cells. The researchers made use of the Opto genetic and photo-pharmacological targeting in order to map the role of the different cells required for the secretion of insulin.

The study clearly states that just the failure of few cells may lead to diabetes. The failure of all the cells is not required. This finding might just lead to the finding of new and better therapies for the disease.


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Explanation of the study

Diabetes Type-2 occurs when the pancreas fails to produce insulin, which means that the glucose in the body stays as glucose and is not converted to energy. The Beta cells form around 65 to 80% of the cells in the islets of pancreas. These cells are responsible for storing and releasing insulin. They respond to fluctuation in the glucose in the blood and accordingly secrete the stored insulin. The new study has shown that only 1 to 10% of all the beta cells, control islet response to glucose.

David Hodson from the University of Birmingham stated that the beta cells seem to serve as pacemakers for the process of insulin secretion. And when the beta cells are silenced the islets are not able to respond to the glucose properly. It was always thought that not all beta cells are equal when it comes to insulin secretion, and now with this study, the concept has been proved.


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In this research the study was conducted on the islet samples collected from murine and human models. The study was conducted with an aim of better understanding of the cell mechanisms. With the help of the study findings it will be easier to find new ways of treating diabetes. Now the focus would be on finding new and better therapies for curing the condition.